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Azide-Propionyl-Val-Cit-PAB(m-PEG8)-MMAE Size:5mg a Mal-Lys(m-PEG4) moiety replaces the

SKU: 44935528863

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Description

a Mal-Lys(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility

265 Purity (HPLC) >= 95% Solubility DMSO

366 SMILES OCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name 4-(methoxy-d3)benzonitrile Synonyms 4-(²H3)methoxybenzonitrile CAS Number  1404321-27-2 Related CAS Molecular Formula C8H7NO Molecular Weight 136

S)-AHPC-CO-PEG5-propargyl Synonyms CAS Number n/a Related CAS Molecular Formula C36H52N4O9S Molecular Weight 716

Azide-Propionyl-Val-Cit-PAB(m-PEG8)-MMAE Size:5mg a Mal-Lys(m-PEG4) moiety replaces theSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing

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