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DBCO-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-PNP Size:50mg Product Name DOTA-C6-amine Synonyms CAS

SKU: 8215968486

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Description

Product Name DOTA-C6-amine Synonyms CAS Number n/a Related CAS Molecular Formula C22H42N6O7 Molecular Weight 502

546 SMILES OCCOCCOCCOCCOCCOCC#CC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

The conventional maleimidocaproyl (MC) unit is replaced by Mal-Propionyl-PEG6 moiety to enhance aqueous solubility

Product Name DOTA-tris(t-Bu)ester-C2-propanamido-maleimide Synonyms CAS Number Related CAS Molecular Formula C37H63N7O10 Molecular Weight 765

while the para-aminobenzyl (PAB) spacer supports self-immolative release of the attached drug

DBCO-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-PNP Size:50mg Product Name DOTA-C6-amine Synonyms CASSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to

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