You have to cast your spells precombat, which you dont always want to do, and on top of that, you need both a creature and noncreature
Not exactly, but first strike blockers can stop a creature with menace
Odds are they can't get mana, which means your lands are protected form being killed with spells by not letting them have any mana
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Naturally, these sorts of shenanigans are easiest to accomplish in a token deck, but any go-wide strategy can reasonably use Ezuris Predation to create an instant board, sweep away weaker opposing creatures, and move toward closing the game