If you don't own any of the staples in this list, replacing them with something else shouldn't cause a dramatic effect on performance
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This answer provides examples of situations where having a larger deck might not be a strict disadvantage
he is easily a good commander if you wanted to try to build a deck around him
GX , the animated series that put Fusion Summoning at the forefront, so the Machine Reactor Structure Deck can be enhanced further with Ancient Gear Fusion Monsters from Raging Tempest and an upcoming Spell Card from Maximum Crisis that will let you Fusion Summon and Tribute Summon using the same 2 monsters in the same turn
